Free radicals trigger TNF?-induced cardioprotection

Role of Nitric-Oxide Synthase, Free Radicals, and Protein Kinase C in Opioid-Induced Cardioprotection

Opioids generate free radicals that mediate protection in isolated cultured cardiomyocytes. We hypothesize that the nature of these radicals is nitric oxide, and that nitric oxide activates the protein kinase C (PKC) isoform. Through this signal transduction pathway, opiates protect cardiomyocytes during hypoxia and reoxygenation. Cell viability was quantified in chick embryonic ventricular myo...

Role of nitric-oxide synthase, free radicals, and protein kinase C delta in opioid-induced cardioprotection.

Opioids generate free radicals that mediate protection in isolated cultured cardiomyocytes. We hypothesize that the nature of these radicals is nitric oxide, and that nitric oxide activates the protein kinase C (PKC) delta isoform. Through this signal transduction pathway, opiates protect cardiomyocytes during hypoxia and reoxygenation. Cell viability was quantified in chick embryonic ventricul...

P-216: Dual Targeting of TNF-? and Free Radicals Toxic Stress as A Promising Strategy to Manage Experimental Polycystic Ovary

Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.

OBJECTIVES Acetylcholine (ACh) receptor activation in the heart causes mitochondrial production of reactive oxygen species (ROS) that is dependent on mitochondrial K(ATP) channel opening. Recent data show that Akt (also known as protein kinase B) is phosphorylated at its activation site following exposure to ACh. However, since no reliable Akt inhibitor is available, it has not been possible to...

Exercise-induced brachial artery vasodilation: role of free radicals.

Originally thought of as simply damaging or toxic "accidents" of in vivo chemistry, free radicals are becoming increasingly recognized as redox signaling molecules implicit in cellular homeostasis. Indeed, at the vascular level, it is plausible that oxidative stress plays a regulatory role in normal vascular function. Using electron paramagnetic resonance (EPR) spectroscopy, we sought to docume...